Day: 23 October 2021
vs 
Witton Albion vs FC United of Manchester
vs 
South Shields vs Buxton
vs 
Grantham Town vs Warrington Town
vs 
Hyde United vs Scarborough Athletic
vs 
Bamber Bridge vs Ashton United
vs 
Lancaster City FC vs Matlock Town
vs 
Basford United vs Radcliffe FC
vs 
Nantwich Town vs Morpeth Town
vs 
Gainsborough Trinity vs Atherton Collieries
vs 